Thalassemia is a hereditary disease in the form of impaired hemoglobin synthesis that occurs due to mutations in the globin gene which is characterized by anemia. The diagnosis of thalassemia requires clinical information and laboratory results, including complete blood count, iron status, radiology examination, Hb analysis, or molecular study. Previous studies have stated that there is a wide array of thalassemia phenotypes and there is common for interactions of thalassemia with other hemoglobinopathies, such as HbE. This can be known, one of which is through the description of the Hb fraction of thalassemia patients which can be examined using Hb electrophoresis. Therefore, this study aims to determine the description of the Hb pattern using Hb electrophoresis in thalassemia patients at regional general hospital/RSUD dr. Zainoel Abidin Banda Aceh. This type of research is descriptive with a cross sectional research design using retrospective data obtained from patient medical records and Hb electrophoresis results were examined using capillary electrophoresis in the Clinical Pathology Laboratory of RSUDZA. The sample of this study were all thalassemia patients who had been diagnosed by pediatricians during 2018-2021 and had Hb electrophoresis results which was first performed at Clinical Pathology Laboratory of RSUDZA, which were 134 patients. The data results showed a wide array of thalassemia patients’s hemoglobin electrophoresis, as such the results of electrophoresis are grouped into several impressions based on the type of globin chain that may have mutations and based on the Hb variants found, namely normal, normal + HbC, α-thalassemia, α-thalassemia + HbC, α-thalassemia + HbCS and HbE, β-thalassemia, β-thalassemia + HbE, β-thalassemia + HbS, β-thalassemia + HbE and HbJ, and β-thalassemia + HbS and HbE. Other Hb variants found were HbH and Hb Bart's which were classified as α-thalassemia.
Keywords: Thalassemia, Hb Pattern, Hb Analysis, Hemoglobin Electrophoresis.