Vaccination is the strategy of the government to increase immunity and break the chain of the spread of COVID-19. The family role is essential in the high-risk group like the elderly to raise the knowledge, attitude, and behavior in performing the vaccination and reducing anxiety during the COVID-19 pandemic. This research used the quantitative descriptive design with a cross-sectional approach. The sampling used proportional sampling to 389 respondents in Banda Aceh. The sampling used a guided interview method with three standard instruments, which are Knowledge, Attitude, and Practice (KAP), Geriatric Anxiety Scale (GAS), and Development of The Family Support Scale (FSS). The result of the research showed that 233 (67.4%) of the elderly respondents in Banda Aceh were willing to get vaccinated. In comparison, 127 (32.6%) of them refused to get vaccinated because of side effects and poor safety (29.3%). Mostly the elderly still have some concerns about the vaccination program (63.0%). The level of the elderly's knowledge about the COVID-19 and COVID-19 vaccination was still in the low category (54.5%), and the anxiety level during the COVID-19 pandemic was in the minimal category (76.6%). Family support was in the high category (45.0%). The health worker team is expected to provide education about vaccine safety, both face-to-face and through the media, to increase vaccine acceptance in the community.